Leading experts share their patient case experiences and discuss emerging evidence to navigate key clinical questions in C3G and primary IC-MPGN, including why treatment timing and individualisation matter in children, what can or can’t be recovered after chronic kidney damage, and how treatment response should be assessed over time in the age of targeted therapies.

Publication
  • ESPN •
  • 2 October, 2026 •
  • •

Pegcetacoplan sustained clinical benefit in adolescent patients with C3 glomerulopathy and primary immune complex membranoproliferative glomerulonephritis through 1 year of therapy: Data from VALIANT/VALE

Christoph Licht, Gema Ariceta, Yael Borovitz, Bradley P Dixon, Naoya Fujita, Antonio Mastrangelo, Nabil Melhem, Nicole Van De Kar, Marina Vivarelli, Dean Wallace, Virginia Taliadouros, Johan Szamosi, Kathryn Gordon, Zhongshen Wang, Carla M Nester

Publication
  • ESPN •
  • 2 October, 2026 •
  • •

Pegcetacoplan treatment response in VALIANT/VALE: Impact of genetic and acquired complement dysregulation and disease type in C3 glomerulopathy and primary (idiopathic) immune complex membranoproliferative glomerulonephritis

Nicole Van De Kar, Marina Norris, Daniel P Gale, Sophie Chauvet, Fernando Caravaca-Fontán, Julia Weinmann-Menke, Bradley P Dixon, Carla M Nester, Lucía Quintana-Gallardo, Johan Szamosi, Kathryn Gordon, Anwesha Mukherjee, Fadi Fakhouri

Publication
  • ESPN •
  • 2 October, 2026 •
  • •

Real-world effectiveness and safety of pegcetacoplan in patients with C3 glomerulopathy or primary immune-complex membranoproliferative glomerulonephritis: PRISM-C3, a multi-country Phase 4 study

David Kavanagh, Matthew C Pickering, Terence Cook, Marina Vivarelli, Moglie Le Quintrec, Véronique Frémeaux-Bacchi, Virginia Taliadouros, Elena Surova, Nicholas Webb, Fadi Fakhouri

Publication
  • ERA •
  • 4 June, 2026 •
  • •

Safety and low incidence of meningococcal infections with pegcetacoplan in C3G / primary IC-MPGN and PNH

Antonio Mastrangelo, Daniel P Gale, Daniel Zecher, Nabil Melhem, Sanya Norouzi, Bradley P Dixon, Sheena Patel, Liza Alkhori Franzén, Gashu Ayehu, Chauncey Clemons, Régis Peffault de Latour

Available materials

Oral Presentation
Publication
  • ERA •
  • 4 June, 2026 •
  • •

Pegcetacoplan sustained clinical benefit in C3G and primary IC-MPGN through 1 year of therapy: Data from VALIANT/VALE

Fadi Fakhouri, Gema Ariceta, Matthew C Pickering, Moglie Le Quintrec, Marina Vivarelli, Carla M Nester, Bradley P Dixon, Virginia Taliadouros, Johan Szamosi, Kathryn Gordon, Anwesha Mukherjee, Christoph Licht

Available materials

Oral Presentation
Publication
  • ERA •
  • 4 June, 2026 •
  • •

Epidemiology of C3G and primary IC-MPGN: a systematic literature review and meta-analysis

Fernando Caravaca-Fontán, Carly Rich, Veruska Carboni, Jameel Nazir, Chris D Poole, Daniel P Gale

Available materials

Poster
Publication
  • ERA •
  • 4 June, 2026 •
  • •

Pegcetacoplan population pharmacokinetics and exposure-response analysis in adolescent and adult patients with C3G or primary IC-MPGN

David Kavanagh, Seung Hyeok Han, Larry A Greenbaum, Bradley P Dixon, Ali Keshavarz, Ryan L Crass, Brandon Smith, Xiaoying Yu, Priska Kaufmann

Available materials

Poster
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